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This methylation profile is presently acquired with the MBL stage3 and continues to be somewhat steady with time. Having said that, some CLL have intratumor variability in certain areas, which can change the expression of various genes and facilitate tumor evolution.71 Of Be aware, this variability is greater in U-CLL than in M-CLL and is also linked to escalating variety of subclones.7,71
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See "Qualified therapies in CLL: mechanisms of resistance and strategies for administration" on page 471.
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102 Alternatively, a number of teams are advocating to the incorporation of novel markers, like a elaborate karyotype55 or epigenetic subsets, 27,28 into clinical apply. All these novel prognostic and/or predictive products will should be validated in cohorts of patients treated with focused brokers.
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